Pyruvate forms in the body when carbohydrates and protein convert into energy.

Pyruvate now comes in supplement form; however, several foods, including red apples, cheese, dark beer, and red wine contain small amounts of pyruvate.

Pyruvate provides energy to the body and is also an antioxidant. Pyruvate enhances weight loss efforts and may improve exercise function.

Pyruvate enhances weight loss efforts.

Pyruvate-rich foods are the best way to get this compound. The average American diet naturally contains about half a gram of Pyruvate, the same amount found in a red apple. If you choose a pyruvate supplement, the common dose is 5 to 6 grams daily for weight loss.

What is pyruvate carboxylase deficiency?

Pyruvate carboxylase deficiency is an inherited disorder that causes lactic acid and other potentially toxic compounds to accumulate in the blood. High levels of these substances can damage the body’s organs and tissues, particularly in the nervous system.

  1. Researchers have identified at least three types of pyruvate carboxylase deficiency, which are distinguished by the severity of their signs and symptoms. Type A, which has been identified mostly in people from North America, has moderately severe symptoms that begin in infancy. Characteristic features include developmental delay and a buildup of lactic acid in the blood (lactic acidosis). Increased acidity in the blood can lead to vomiting, abdominal pain, extreme tiredness (fatigue), muscle weakness, and difficulty breathing. In some cases, episodes of lactic acidosis are triggered by an illness or periods without food (fasting). Children with pyruvate carboxylase deficiency type A typically survive only into early childhood.
  2. Pyruvate carboxylase deficiency type B has life-threatening signs and symptoms that become apparent shortly after birth. This form of the condition has been reported mostly in Europe, particularly France. Affected infants have severe lactic acidosis, a buildup of ammonia in the blood (hyperammonemia), and liver failure. They experience neurological problems including weak muscle tone (hypotonia), abnormal movements, seizures, and coma. Infants with this form of the condition usually survive for less than 3 months after birth.
  3. A milder form of pyruvate carboxylase deficiency, sometimes called type C, has also been described. This type is characterized by slightly increased levels of lactic acid in the blood and minimal signs and symptoms affecting the nervous system.

Pyruvate carboxylase deficiency is a rare condition, with an estimated incidence of 1 in 250,000 births worldwide. This disorder appears to be much more common in some Algonkian Indian tribes in eastern Canada.

Side Effects

Most people don’t suffer any side effects. However, large amounts (10 grams per day or more) can trigger stomach upset, bloating, gas and diarrhea.

Read More: Essential Nutrients