PrimeGENIX CortiSync Review: Best Supplement to Reduce Cortisol in 2023

Last Updated: 4 October 2023

Stress is a natural response to our fast-paced, competitive world. When we feel under pressure, our bodies release hormones like adrenaline and cortisol, which help us fight or flight. While stress can be helpful in certain situations, it can also take a toll on our physical and mental health if we constantly feel overwhelmed.

Chronic stress can lead to problems like anxiety, depression, insomnia, and heart disease. Finding ways to manage stress is important, so it doesn’t get out of control.

Some people try to reduce stress by intake caffeine and meditating. While these may work for some people, others find it difficult to manage stress.

This is where supplements come in.

Many supplements on the market claim to control cortisol levels, but most use substandard ingredients.

Here, you will read about PrimeGENIX CortiSync, the best natural supplement to control your cortisol levels.

Let’s explore and read more about this best cortisol-reducing supplement.

PrimeGENIX CortiSync Quick Overview

Product CategoryNatural Supplement to Reduce Cortisol
Product ClaimNaturally Reduce Cortisol In 2 Weeks
BrandPrimeGENIX (Offering 4 Quality Fitness Supplements)
ManufacturerLeading Edge Health (Offering Fitness Supplements since 2001)
Active Ingredients
  • Sensoril-Ashwagandha Root Extract – 300mg
  • Lemon Balm Powder – 150mg
  • Lichi Extract – 120mg
  • L-Theanine – 100mg
  • Holy Basil extract – 100mg
  • Magnolia bark extract – 100mg
  • Rhodiola root extract – 50mg
  • Enhances Physical Performance
  • Boosts Strength & Energy
  • Improves Metabolic Functions
  • Increases Focus, Memory & Attention-Span
Key Features
  • Doctor Recommended Stress Management Suppplement
  • Stimulant-Free Stress Reliever
  • Natural Stress Reliever Supplement
  • Doctor-recommended Stress Reliever
  • Clinically Tested Ingredients
  • Generally Recognized As Safe
  • FDA Registered & Inspected Facilities
  • cGMP Certified Manufacturing
  • Formulated with Patented Ingredients
  • Designed to Support Men’s Health
  • No Prescription Required
  • NON-GMO, Organic, Vegetarian, Kosher, Halal
  • Free Shipping on Bulk Orders
  • 67 Day Money-back Guarantee
  • Save $99 on Bulk Orders
Where to Buy CortiSync?
Official Website:

PrimeGENIX CortiSync Review

When it comes to managing stress, many people turn to dietary supplements in hopes of finding relief. PrimeGenix CortiSync is one supplement made from natural ingredients to lower cortisol levels.

Cortisol is a stress hormone that can negatively affect energy and weight. But CortiSync’s dual-patented formula includes 7 strong adaptogens that stop cortisol from being released in response to stress. This, in turn, may help to improve energy levels and promote weight loss. In addition, the adaptogens in CortiSync also help to improve focus and mental clarity.

Buy PrimeGENIX CortiSync

What is Cortisol?

Hormones are chemicals in your body that coordinate different functions by carrying messages through your blood to your organs, skin, muscles and other tissues. Your body’s inside, and outside organs take a message from them about what to do and when to do it.

According to WebMD, the cortisol hormone is nature’s built-in alarm system in your body. It’s your body’s main stress hormone. It works with certain brain parts that control your mood, motivation, and fear. Your adrenal glands make and release cortisol hormone.

How Does Cortisol Affect Your Body?

Your hypothalamus and pituitary gland release cortisol if your blood contains a low cortisol level. Most of your body cells have cortisol receptors that receive and use the hormone differently.

When your body is on high alert for any fear, motivation or desire, cortisol can alter or shut down functions that get in the way. These may include your digestive or reproductive systems, immune system, or growth processes.

Cortisol plays an important role in many of your body functions. For example, cortisol:

  • Manages how your body uses carbohydrates, fats, and proteins
  • Regulates inflammation
  • Controls your blood pressure
  • Manages your blood sugar (glucose)
  • Controls your sleep/wake cycle
  • Boosts energy so you can handle stress and restores balance afterwards

So, managing cortisol levels to maintain a healthy life is of utmost necessity.

Cortisol and Stress Response

Symptoms of High-Stress Levels or High Cortisol Levels

  • Feeling exhausted, completely drained and tired all day long
  • Especially craving sweets and fatty foods
  • Sometimes suddenly, specifically around the belly, face and hips
  • Feeling weaker throughout the body and muscles take longer to recover
  • Trouble focusing and staying on task, murdering productivity
  • Frequently skipping workouts and avoiding physical activities

How Does CortiSync Work to Regulate Cortisol and Manage Stress Levels?

Cortisol and stress are directly related to each other. High-stress levels can trigger your body to release more cortisol, which causes many health dysfunctions, including increased mental fog and muscle weakness.

PrimeGENIX CortiSync is an effective supplement for stress management because it claims to target the root cause of high cortisol levels, which is the hyperfunctioning adrenal glands.

Studies suggest that too much stress can force your adrenal glands to be “overactive.” When this happens, cortisol levels flood your body uncontrollably. You can’t control it even if you’re practising yoga or other stress-managing techniques.

PrimeGENIX CortiSync is formulated with a powerful blend of natural vitamins, minerals, and plant-based ingredients, which help you manage cortisol levels without turning to prescription drugs.

CortiSync uses adaptogens to control adrenal activity. The adaptogens in Cortisyn help normalize your adrenal function for optimal cortisol levels. Studies show the adaptogens in Cortisync work by supporting your adrenal glands, helping to address the root cause of high cortisol.

Many of the adaptogens in Cortisync have been used for centuries. These are natural stress management plants and herbs linked to powerful hormone-balancing effects.

The manufacturer claims that CortiSync’s potent, proven ingredients can reduce fatigue by seven times and raise endothelial function by up to 91%. Endothelial function is essential for optimal daily energy levels.

PrimeGENIX claims their high-quality supplement can help balance your cortisol levels in just two weeks.

PrimeGENIX CortiSync Pros and Features - The Best Research-based Stress Reliever

PrimeGENIX CortiSync Benefits

Following are some of the benefits of CortiSync based on different clinical trials, studies and research on either CortiSync or its ingredients.

Managing Stress Levels Naturally

The first and foremost benefit of CortiSync is to manage your adrenal activity and regulate the cortisol-releasing phenomenon. Many studies recommend that the adaptogens in CortiSync have been used for centuries to reduce cortisol levels and manage stress.

In a double-blind, placebo-controlled clinical study, a U.S. patented adaptogen in CortiSync significantly reduced cortisol and helped enhance resistance to both physical & emotional stress. This is the cortisol-reducing power of a single adaptogen used in the CortiSync breakthrough formula. You can imagine the power of all seven adaptogens in the CortiSync formula.

CortiSync is a unique blend of seven cortisol-reducing adaptogens. The PrimeGENIX research team carefully selected these seven adaptogens because of the rock-solid evidence for optimizing cortisol levels.

Each adaptogen in the CortiSync formula is backed by research from either human clinical trials or in-vivo and in-vitro studies, including hundreds of scientific papers published in prestigious journals worldwide. (That you will see in the ingredients section below)

Increasing Strength & Endurance Surge While Exercising

If you live an active lifestyle, you know how important it is to perform at your best. Whether running a marathon or lifting weights, cortisol can profoundly impact your results. High cortisol levels can cause a serious lack of motivation, fatigue, decreased strength, and impaired exercise performance.

PrimeGENIX CortiSync is designed to help balance cortisol levels and improve exercise performance. In a clinical study, one of the adaptogens in CortiSync helped significantly improve exercise performance for both bench press and squat.

As a result, CortiSync can help you push through even the most gruelling exercise with extra power. So if you’re looking for an edge in your next workout, try CortiSync. You could finally start feeling your motivation soar, your strength surge, and your energy skyrocket.

Controlling Cortisol-Induced Weight Gain

No one likes carrying extra weight, especially in the form of belly fat. And it’s even more frustrating when you can’t seem to lose it, no matter how hard you try. If you’re struggling with weight gain, it could be due to high cortisol levels in your body. Cortisol is a hormone that helps to regulate your body’s metabolism, and when it’s out of balance, it can lead to difficulty losing weight.

Luckily, CortiSync helps to rebalance your cortisol levels and improve your metabolism. With CortiSync, you can finally start seeing results from your weight loss efforts without putting in extra work. So if you’re looking for a way to lose weight effectively, CortiSync may be the answer you’re looking for.

Boosting Your Productivity and Focus

Men suffering from high cortisol levels often struggle to pay attention and experience memory problems, too. That’s why the cognitive boosting benefits of CortiSync are so exciting. In a clinical study, a cortisol-reducing compound helped improve cognitive functions in just 2 weeks. And by the end of the study, the volunteers had nearly doubled their focus!

Can you imagine feeling 2X more focused at work? Your productivity levels could skyrocket. And instead of feeling “tense” and unproductive, you could feel calm, cool and relaxed, even in stressful situations, like working under tight deadlines. If you’re looking for a way to boost your productivity and improve your cognitive function, CortiSync may be worth considering.

Improving the Sleep Quality and Waking-Up Refreshed and Fully Recharged

We’ve all been there before – lying in bed, trying to fall asleep, but our minds just won’t shut off. For some of us, this is an occasional occurrence. But for others, it’s a nightly battle. If you frequently wake up during the night or struggle to fall asleep in the first place, it could be due to high cortisol levels. Cortisol is a stress hormone that can cause anxiety and interfere with sleep.

CortiSync has been shown to dramatically improve sleep quality, with one study reporting an astonishing 70% improvement in the ability to sleep. So if you’re looking for a peaceful night’s rest, CortiSync could be the answer you’ve been searching for. Wake up feeling refreshed, recharged and renewed – both physically and mentally!

Reducing Inflammation and Improving Bone Density

The effects of high cortisol levels in men can be far-reaching and debilitating. It can lead to inflammation, bone loss and joint pain and make it difficult to stay active and participate in sports or other forms of exercise. The shoulders, wrists and knees are often the first joints to be affected, with symptoms such as cracking, popping and stiffness making it feel as though one is much older than their actual age.

In addition to the physical effects, high cortisol levels can also lead to feelings of anxiety and depression, further negatively impacting one’s quality of life.

The ingredients in CortiSync are packed with inflammation-soothing benefits and powerful antioxidants. This makes them ideal for decreasing stiffness, supporting joint health, and promoting bone mineralization. Plus, our formula helps build strong bones by providing essential nutrients for bone growth and maintenance. As a result, CortiSync is an excellent way to support your health as you age.

Boosting Energy the Whole Day

Low energy is one of the most common complaints among men with high cortisol levels. That’s because cortisol, the “stress hormone,” can wreak havoc on your metabolism, leading to fatigue and exhaustion. But the good news is that a natural solution can help.

CortiSync, a unique formula containing adaptogenic herbs, Ashwagandha and Rhodiola, has been shown in clinical studies to reduce fatigue by 7X and improve endothelial function by 91% – which is critical for boosting your daily energy levels.

Just imagine feeling “balanced” during the day… fully energized…without struggling with mid-day fatigue.

CortiSync could be the answer you’ve been looking for if you’re struggling with low energy.

Buy CortiSync, Try it today and see for yourself!

PrimeGENIX CortiSync Pros

  • Doctor-recommended Stress Reliever
  • Clinically Tested Ingredients
  • Enhances Physical Performance
  • Boosts Strength & Energy
  • Improves Metabolic Functions
  • Increases Focus, Memory & Attention-Span
  • Generally Recognized As Safe
  • FDA Registered & Inspected Facilities
  • cGMP Certified Manufacturing
  • Formulated with Patented Ingredients
  • Designed to Support Men’s Health
  • No Prescription Required
  • No Negative Side-Effects
  • No Doctor Visits
  • Organic
  • Vegetarian
  • Kosher
  • Halal
  • Free Shipping
  • 67 Day Money-back Guarantee

PrimeGENIX CortiSync Cons

  • Available from the official website only
  • Not recommended for minors
PrimeGENIX CortiSync - Best Stress Reliever

PrimeGENIX CortiSync Ingredients

CortiSync is a unique formula that combines herbs and adaptogens to help your body reduce cortisol production. Together, the ingredients help you better manage your stress, which leads to improved physical and mental health.

Following are the ingredients of PrimeGENIX CortiSync.

#1. Sensoril: Patented Ashwagandha Extract

Sensoril is based on Ashwagandha, an Ayurvedic herb with a long history of use for these purposes. What sets Sensoril apart from other ingredients is its high content of bioactive compounds. These special compounds are responsible for the herb’s stress-reducing effects, and the patented form of ashwagandha in Sensoril has the highest level of these compounds of any supplement on the market.

In one study, participants taking Sensoril experienced:

  • Reduce stress by 62%
  • Improve sleep by 70%
  • Lower cortisol levels by 15%

These results are compared to zero improvements in the placebo group. In addition, Sensoril is backed by 12 human clinical studies, so you can be confident in its ability to help you manage stress and feel your best.

#2. Holy Basil

Holy Basil, also known as tulsi, is a green leafy plant native to India. It is considered a sacred herb in Ayurvedic medicine and has been used traditionally for over 3,000 years to promote wellness in the body, mind and soul. Holy Basil is an adaptogen which helps the body “fight off” all types of stress.

It can even help regulate metabolic stress (a type of stress that occurs during exercise) and defend against adrenal fatigue (which is critical for balancing your cortisol levels). Exciting new research confirms that Holy Basil promotes wellness throughout the entire body. With so many potential health benefits, it’s no wonder that Holy Basil is considered a “miracle” herb.

#3. L-Theanine

L-Theanine is an extensively studied phytochemical known for promoting relaxation without drowsiness. It’s found in tea and also offers extraordinary cognitive enhancing benefits.

That’s because it crosses the blood-brain barrier to “turn up” alpha wave activity in the brain for better mental performance, like increased attention span and better memory. Researchers also discovered powerful “anti-ageing” effects, protecting against age-related cognitive decline.

In one study, L-theanine significantly improved performance on tests measuring attention and reaction time. L-theanine has also been shown to protect against age-related cognitive decline.

Overall, L-theanine is a powerful phytochemical with many health benefits. Its ability to promote relaxation without drowsiness and its cognitive enhancing and anti-ageing effects make it a valuable addition to any natural health regimen.

#4. Lemon Balm

Lemon Balm is a small plant native to Europe, with a long history of medicinal use. It was recommended by Swiss physician and philosopher Paracelsus for people suffering from nervous system disorders.

Modern science shows us that Lemon Balm is a powerful way to improve mood and boost cognitive function. In one clinical study, volunteers taking lemon balm extracts significantly increased mood, calmness and alertness.

This “ancient” stress reliever also helps reduce inflammation and promotes deep sleep. Consequently, Lemon Balm is an effective natural remedy for anxiety, stress and insomnia. Furthermore, its ability to improve cognitive function makes it a valuable treatment for Alzheimer’s disease and other brain degenerative disorders.

#5. Lichi

It’s no wonder that the Litchi fruit has been coveted for centuries. This delicious fruit tastes not only great but also has many health benefits. Modern science has shown that the bioactive compounds in Lichi help reduce stress and cortisol levels while promoting weight loss. That’s because they help optimize metabolic activities.

Studies have also shown that Lichi helps build strong bones and reduces inflammation throughout the body. But that’s not all – this “super” fruit is also rich in micronutrients, including vitamins B1, B2, B3, B6, C, E, and K, as well as several health-boosting minerals. So if you’re looking for a delicious and nutritious fruit to add to your diet, look no further than Lichi.

#6. Magnolia

The Magnolia tree has a long and rich history of medicinal use in both Japanese and Chinese cultures. The cultivation of the Magnolia tree dates back to the ancient Aztecs, traditionally used for reducing anxious feelings and decreasing inflammation. Studies show that the active compounds in Magnolia make it easier to fall asleep.

The Magnolia tree is also known for boosting serotonin levels in the brain, which improves mood and promotes relaxation. Researchers also believe that the stress-reducing effects of Magnolia make it easier to lose weight. This way, you could feel more relaxed while finally watching the weight practically “fall off” without any extra effort than your normal exercise routine.

#7. Rhodiola

Rhodiola Rosea is a perennial flowering herb that grows in the mountainous regions of Europe and Asia. The root of the plant has been used for centuries in traditional medicine for its wide range of health benefits. Modern science has confirmed that Rhodiola is an effective adaptogen, which helps the body adapt to stressful situations. Studies have shown that Rhodiola can help to reduce cortisol levels, making it an ideal natural remedy for stress and anxiety.

Rhodiola has also been shown to boost cognitive performance and reduce fatigue, making it a valuable tool for astronauts and other high-performance individuals. In addition, Rhodiola demonstrates powerful anti-ageing effects, with one study showing that it can increase maximum lifespan by up to 31%. These findings suggest that Rhodiola may be a valuable ally for anyone looking to improve their health and well-being.

Frequently Asked Questions about PrimeGENIX CortiSync

What is PrimeGENIX CortiSync?

CortiSync by PrimeGENIX is an all-natural supplement designed to help normalize the body’s response to stress. The dual-patented formula includes clinically proven ingredients that target the adrenal glands and help balance cortisol levels in men. It works to stop your body from reacting to stress while lowering cortisol levels.

PrimeGENIX claims that regularly supplementing with CortiSync can:

  • Boost mental clarity, attention span, and focus
  • Improve endothelial and metabolic function
  • Decrease high-stress levels
  • Improve sleep pattern
  • Enhance physical performance
  • Raise strength and energy levels
  • Lower chances of insomnia
  • Aid in weight loss
  • Reduce fatigue and depression
  • Reduce blood sugar and blood pressure

Does CortiSync Really Work?

The key to CortiSync’s effectiveness is its unique blend of ingredients. Ashwagandha, for example, is an adaptogen that helps the body adapt to stress by reducing the production of cortisol, the stress hormone. Rhodiola Rosea is another key ingredient. It’s been shown to help improve mental focus and cognitive function. Together, these ingredients provide a powerful way to reduce stress and improve overall health.

In addition to the herbs and adaptogens in CortiSync, the formula also includes vitamins B6 and B12. These vitamins are essential for maintaining energy levels and aiding in the production of red blood cells. By helping your body reduce cortisol production and providing essential nutrients, CortiSync provides a comprehensive solution for stress management.

How to Take CortiSync?

The recommended dosage is 2 capsules at any time of the day, with a meal. Do not take more than the maximum daily dosage for any reason.

What If I am not Satisfied with CortiSync?

The manufacturer has a 67-day money-back guarantee. If you want to return the products, contact the customer service department by phone or email for instructions. Then send the order back within 67 days, even if the bottles are empty. You should get a full refund.

Does CortiSync Have Any Side Effects?

CortiSync ingredients have been widely researched and found to be a safe, natural way to regulate cortisol levels. No harmful side effects have been reported for the ingredients or the CortiSync formula.

In addition to the safety of the individual ingredients, each bottle of CortiSync has been evaluated by independent laboratories for purity, potency, and quality. Natural supplements, especially doctor-recommended ones like CortiSync, are generally safe for consumption for most people over the age of 18.

Will I feel sleepy or tired with CortiSync?

No. The whole point of this remedy is to help consumers fight fatigue. It improves energy levels.

Will using CortiSync help with blood sugar issues?

Yes. The ingredients found in this formula can reduce blood sugar and blood pressure.

What’s with the CortiSync money-back guarantee?

The manufacturer offers 67 days money back guarantee to ensure that customers are either happy with the product or satisfied with their refund. Unsatisfied users need to get in touch with the customer service team for a refund.

Where to Buy PrimeGENIX CortiSync?

You can buy PrimeGENIX CortiSync only from the official website. Don’t take risk of buying CortiSync from any other source. CortiSync is not availabe on Amazon, WalMart, eBay or any other store.

Concluding PrimeGENIX CortiSync Review

PrimeGENIX CortiSync is an all-natural dietary supplement that deploys the power of 7 adaptogens to lower and balance cortisol levels in your body.

Furthermore, it helps improve mood, decrease stress, boost cognitive performance, provides added energy, strengthen immunity, and promotes weight loss, among other benefits. A famous doctor recommends it for cortisol-reducing purposes.

This quality supplement blend includes only 100% organic ingredients, with no steroid, stimulant, chemical or artificial additives or fillers. It’s manufactured in an FDA-certified facility following GMP standards.

Sources & References

At, we rely on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references.

  • Cortisol:
  • Neurotransmitters:
  • Effect Of Ashwagandha (Withania Somnifera) Extract On Sleep: A Systematic Review And Meta-Analysis:
  • Jamshidi N, Cohen MM. The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evid Based Complement Alternat Med. 2017;2017:9217567. doi: 10.1155/2017/9217567. Epub 2017 Mar 16. PMID: 28400848; PMCID: PMC5376420.
  • Anghelescu, Ion & Edwards, David & Seifritz, Erich & Kasper, Siegfried. (2018). Stress management and the role of Rhodiola rosea : a review. International Journal of Psychiatry in Clinical Practice. 22. 1-11. 10.1080/13651501.2017.1417442.
  • Hirotsu C, Tufik S, Andersen ML. Interactions between sleep, stress, and metabolism: From physiological to pathological conditions. Sleep Sci. 2015 Nov;8(3):143-52. doi: 10.1016/j.slsci.2015.09.002. Epub 2015 Sep 28. PMID: 26779321; PMCID: PMC4688585.
  • Hua, Yanjun & Zhuang, Qingqi. (2012). The role of Magnolia officinalis in releasing stress and controlling weight. Pharmaceutical Care and Research. 12. 476-478. 10.5428/pcar20120624.
  • Miraj S, Rafieian-Kopaei, Kiani S. Melissa officinalis L: A Review Study With an Antioxidant Prospective. J Evid Based Complementary Altern Med. 2017 Jul;22(3):385-394. doi: 10.1177/2156587216663433. Epub 2016 Sep 11. PMID: 27620926; PMCID: PMC5871149.